Microdomains in the Cardiovascular System

The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future. This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.

Receptor-cyclic nucleotide microdomains in the heart. - Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes. - Function to Failure: Compartmentalization of Cardiomyocyte Signaling by A-Kinase Anchoring Proteins. - Pharmacological approaches for delineating functions of AKAP-base signalling complexes and finding therapeutic targets. - Chatting second messengers: PIP3 and cAMP. -Cyclic nucleotide phosphodiesterases and compartmentation in normal and diseased heart. -cAMP compartmentalisation and hypertrophy of the heart: `good pools of cAMP and `bad pools of cAMP coexist in the same cardiac myocyte. - Subcellular targeting of PDE4 in cardiac myocytes and generation of signaling compartments. - Cardiac cAMP microdomains and their modulation using disruptor peptides. - Computational modelling of cyclic nucleotide signaling mechanisms in cardiac myocytes. - SIGNALING MICRODOMAINS: THE BETA3 ADRENERGIC RECEPTOR/NOS SIGNALOSOME. - Compartmentation of natriuretic peptide signalling in cardiac myocytes effects on cardiac contractility and hypertrophy. - Cyclic GMP/Protein Kinase Localized Signaling and Disease Implications. - Distribution and regulation of L-type Ca ²⁺ channels in cardiomyocyte microdomains. - The Role of Local Ca ²⁺ Release for Ca ²⁺ Alternans and SR Ca ²⁺ Leak . - The control of sub-plasma membrane calcium signalling by the plasma membrane calcium ATPase pump PMCA4. - Calcium microdomains in cardiac cells.