these "tauopathies" are reviewed by Delacourte. Therecentdiscoverythatmutationsofthetaugenearecausativeforfamilial formsoffrontotemporaldementiaandParkinsonism(FTDP-17)broughtthe "taupathway"and the"tauopathies"tothecentrestage.Thisextraordinary breakthroughwillbecoveredbySpillantiniandGoedert.Thereisincreasing evidence that argyrophilic grain disease is much more frequent in older patients than previously thought. Tolnay et al. are reviewing recent contributionstothepathologyofthislate-onsetdementingdisorderinwhich ofamyloidbetadeposits,isalmost taupathology,inthealmosttotalabsence exclusivelyrestricted to the limbic lobe and the amygdala. Schultzet al. report an intriguing age-related progression of neuronal and glial tau pathologyinbaboonsthusrenderingthe baboonapotentialprimatemodel forage-relatedhuman"tauopathies". Gotzetal. introducetransgenicmice expressingmutated human tau as valuable animal models for reproducing formationofneuro-andglialfibrillarylesions.
Inhaltsverzeichnis
Can the Physician Predict the Neuropathologist? . - The Molecular Parameters Of Tau Pathology. - Tau as a killer and a witness. - Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17. - Argyrophilic Grain Disease. - A frequent dementing disorder in aged patients. - Tau Pathology in Neurons and Glial Cells of Aged Baboons. - Human Tau Transgenic Mice. - Towards an animal model for neuro-and glialfibrillary lesion formation. - Regulation of Alzheimer 13-Amyloid Precursor Trafficking and Metabolism. - Role of Type 10 1713-Hydroxysteroid Dehydrogenase in the Pathogenesis of Alzheimer s Disease. - The Spectrum Of Vascular Disease In Dementia. - From ischemia to amyloid angiopathy. - Transgenic Mouse Models of Cerebral Amyloid Angiopathy. - Alpha-Synuclein. - Axonal transport, ligand interaction and neurodegeneration. - Dementia with Lewy Bodies. - Mouse Models of ? -Synucleinopathy and Lewy Pathology. - ? -synuclein expression in transgenic mice. - Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases. - Perisomatic Granules of Hippocampal CA1 Neurons in Alzheimer s Disease, Pre-Alzheimer Stage and Pick s Disease: an Overlooked Pathological Entity. - Ubiquitin and the Molecular Pathology of Neurodegenerative Diseasespathological Mechanisms in Polyglutamine Expansion Diseases. - Dementia in the Neuronal Ceroid-Lipofuscinoses. - Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis. - Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing.
