The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman's famous statement "What I cannot create, I do not understand."
Inhaltsverzeichnis
Electrochemical Biosensors for miRNA Detection. - Electrochemical Detection of RNA. - DNA and PNA probes for DNA Detection in Electroanalytical Systems. - DNA for Non-Nucleic Acid Sensing. - Aptamers in Oncotherapy. - Genotyping of Single Nucleotide Polymorphism. - Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA. - Fluorescent Nucleic Acid Analogues in Research and Clinical Diagnostics. - Emergent Properties and Functions of Nanoconfined Nucleic Acid Architectures. - RNA and DNA Diagnostics on Microspheres: Current and Emerging Methods. - DNA and RNA Electronic Properties for Molecular Modifications and Environmental State Diagnostics. - Mechanochemical Sensing. - Microarrays as Research Tools and Diagnostic Devices. - Quadruplex Priming Amplification (QPA) for Nucleic Acid Diagnostics. - Single-molecule strategies for DNA and RNA diagnostics. - Detection and Assessment of microRNA Expression in Human Disease.
