Methods in Hormone Research, Volume IV: Steroidal Activity in Experimental Animals and Man, Part B focuses on protection against irradiation damage, anti-mammary tumor activity, anti-androgens, steroids, and anti-progestational compounds.
The selection first offers information on the thermogenic properties of steroids and anabolic steroids, as well as characteristics of steroid pyrogen action in man; species specificity of steroid pyrogen action; clinical significance of thermogenic steroids; and relative activity of anabolic steroids in animals and man. The book also ponders on anti-androgens and anti-progestational compounds.
The manuscript examines steroids in reactivated prostatic cancer and tumorigenesis in experimental animals. Discussions focus on treatment and nature of relapse, cooperative study program, mammary and pituitary tumors, testicular interstitial cell tumors, and neoplasms of the female genital tract. The text then elaborates on inhibition of tumor growth by steroids and the effect of corticoids and ACTH on the induction of gastric ulcers in laboratory animals.
The selection is a dependable reference for readers interested in steroidal activity in man and animals.
Inhaltsverzeichnis
1;Front Cover;1 2;Steroidal Activity in Experimental Animals and Man, Part B;4 3;Copyright Page;5 4;Table of Cotents;10 5;CONTRIBUTORS TO VOLUME IV;6 6;PREFACE;8 7;CONTENTS OF PREVIOUS VOLUMES;12 8;Chapter 1. Thermogenic Properties of Steroids;14 8.1;I. Introduction;14 8.2;II. Thermogenic Action of Progesterone;15 8.3;III. Steroid Pyrogens: C19 Series;17 8.4;IV. Steroid Pyrogens: C21 Series;19 8.5;V. Steroid Pyrogens : C24 Series;20 8.6;VI. Steroid Pyrogen Conjugates;21 8.7;VII. Species Specificity of Steroid Pyrogen Action;22 8.8;VIII. Characteristics of Steroid Pyrogen Action in Man;23 8.9;IX. Metabolism of Steroid Pyrogens;27 8.10;X. Mechanisms of Steroid Fever;28 8.11;X I. Clinical Significance of Thermogenic Steroids;29 8.12;References;30 9;Chapter 2. Anabolic Steroids;34 9.1;I. Introduction;34 9.2;II. Relative Activity in the Animal;35 9.3;III. Relative Activity in Man;77 9.4;References;84 10;Chapter 3. Anti-Androgens;90 10.1;Text;90 10.2;References;106 11;Chapter 4. Anti-Progestational Compounds;108 11.1;Text;108 11.2;References;117 12;Chapter 5. Steroids in Reactivated Prostatic Cancer;118 12.1;I. Treatment of Relapse;119 12.2;II. Experimental Prostatic Cancer ;121 12.3;III. The Cooperative Study Program;123 12.4;IV. The Nature of Relapse;127 12.5;V. Summary and Conclusions;132 12.6;References;133 13;Chapter 6. Steroids and Tumorigenesis in Experimental Animals;136 13.1;I. General Considerations ;136 13.2;II. Mammary Tumors;141 13.3;III. Testicular Interstitial Cell Tumors ;153 13.4;IV. Pituitary Tumors;161 13.5;V. Neoplasms of the Female Genital Tract;164 13.6;VI. Renal Tumors in the Hamster;166 13.7;VII. Lymphoid Tumors in Mice;167 13.8;VIII. Miscellaneous Considerations;170 13.9;References;173 14;Chapter 7. Inhibition of Tumor Growth by Steroids;178 14.1;Text;178 14.2;References;202 15;Chapter 8. Effects of Steroids on the Pancreas;206 15.1;I. Introductory Information Concerning the Pancreas;206 15.2;II. Steroids and the Endocrine Pancreas;208 15.3;III. E
ffects of Steroids on the Exocrine Pancreas;232 15.4;IV. Summary;240 15.5;References;241 16;Chapter 9. Effects of Corticoide and ACTH on the Induction of Gastric Ulcers in Laboratory Animals;248 16.1;I. Methodology;249 16.2;II. The Normal Stomach as Influenced by Corticoids and ACTH;261 16.3;III. Influence of Corticoids and ACTH on the Development of Artificial Gastric Ulcers;268 16.4;IV. Healing of Gastric Ulcers as Influenced by Corticoids and ACTH ;277 16.5;V. Relation between Gastric and Other Effects of Corticoids;278 16.6;VI. Experimental Data and Clinical Features;280 16.7;References;282 17;Chapter 10. The Influence of Steroids on ß- Glucuronidase of Mouse Kidneys;286 17.1;I. Introduction;286 17.2;II. Renal ß-Glucuronidase Response;289 17.3;III. Studies on Biological Mechanisms;325 17.4;References;338 18;AUTHOR INDEX;340 19;SUBJECT INDEX;358
