Diabetic Retinopathy

Beschreibung

Diabetic retinopathy is the most common microvascular complication of diabetes. It remains a major cause of new-onset visual loss in the United States and other industrialized nations. In Diabetic Retinopathy, Elia Duh and a panel of internationally recognized experts comprehensively assess the current state of knowledge regarding the clinical management of DR as well as its underlying mechanisms. The authors outline the current understanding of diabetic retinopathy from the perspective of clinical practice, while reviewing the multi-factorial pathogenesis and pathophysiology of DR from the standpoint of biomedical research. Also included is a discussion of emerging concepts relating to the management and treatment of DR. Informative and highly-practical, Diabetic Retinopathy provides ophthalmologists, diabetologists, endocrinologists, and internists with a highly readable guide not only to understanding diabetic retinopathy, but also to its optimal clinical management. TOC:Nonproliferative Diabetic Retinopathy.- Proliferative Diabetic Retinopathy.- Epidemiology of Diabetic Retinopathy.- Diagnostic modalities in Diabetic Retinopathy.- In vivo models of diabetic retinopathy.- The Polyol Pathway and Diabetic Retinopathy.- The Role of Advanced Glycation in Diabetic Retinopathy.- The Role of Protein Kinase C in Diabetic Retinopathy.- Oxidative Stress in Diabetic Retinopathy.- Pericyte Loss in the Diabetic Retina.- Capillary Dropout in Diabetic Retinopathy.- Neuroglial Dysfunction in Diabetic Retinopathy.- The Role of Inflammation in the Pathophysiology of Diabetic Retinopathy.- Vascular Permeability in Diabetic.- Retinal neovascularization and the role of VEGF.- Beyond VEGF - Other Factors Important in Retinal Neovascularization: Potential Targets in Proliferative Diabetic Retinopathy.- Anti-VEGF therapy as an emerging treatment for diabetic retinopathy.- Clinical Trials in Protein Kinase C-ß Inhibition in Diabetic Retinopathy.- The role of intravitreal steroids in the management of diabetic retinopathy.- Antagonism of the Growth Hormone Axis as a Therapeutic Strategy for Diabetic Retinopathy.- Diabetic Retinopathy and Systemic Complications.