Die 'Trainspotting'-Crew zehn Jahre später: Immer noch tobt der Kampf um die obersten Stufen der Karriereleiter. Dabei gibt es Reibungsverluste. Davon können Simon 'Sick Boy' Williamson und Mark Renton ein Lied singen.
Ten years on from Trainspotting Sick Boy is back in Edinburgh after a long spell in London. Having failed spectacularly as a hustler, pimp, husband, father and businessman, Sick Boy taps into an opportunity which to him represents one last throw of the dice. However, to realise his dream of directing and producing a pornographic movie, Sick Boy must team up with old pal and fellow exile Mark Renton. In the world of Porno, though, nothing is straightforward, as Sick Boy and Renton find out that they have unresolved issues to address concerning the increasingly unhinged Frank Begbie, the troubled, drug-addled Spud, but, most of all, with each other.