Vascular Disease and Injury

A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.

I Acute Mechanical Injury and Vascular Repair. - 1 Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries. - 2 The Porcine Model of Coronary Restenosis. - 3 Atherosclerotic Porcine Coronary Stent Model: Technical Methods for Preclinical Studies. - 4 Nonhuman Primate Models of Arterial Injury and Repair. - 5 Experimental Models of Arteriovenous Grafting. - 6 Wire Denudation and Ligation Models of the Mouse Carotid Artery. - 7 Endothelial Denudation and Arterial Dilation in the Mouse. - 8 Vascular Photochemical Injury in the Mouse. - 9 Mouse Model of Transluminal Femoral Artery Injury. - II Models of Arterial Thrombosis. - 10 A Murine Model of Arterial Injury and Thrombosis. - 11 Folts Cyclic Flow Animal Model for Studying In Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls. - III Chronic Atherosclerotic Models. - 12 Mouse Models of Atherosclerosis. - 13 Rabbit Models of Atherosclerosis. - 14 Atherosclerosis in Nonhuman Primates. - IV Vascular Disease in Transplanted Vessels. - 15 Murine Carotid Loop Model of Transplant Vascular Disease. - 16 Murine Heterotopic Model of Transplant Arteriopathy. - 17 Hyperacute Vascular Rejection: Lessons from Pig-to-Primate Xenotransplantation. - V Vascular Disease in Models of Arterial Hypertension. - 18 Methods for Examining Cerebrovascular Disease in Experimental Models of Hypertension. - 19 Monocrotaline-Induced Pulmonary Hypertension in Rats. - 20 Chronic Pulmonary Hypertension in the Hypoxic Rat and in the Sheep Following Continuous Air Embolization. - VI Animal Care and Tissue Processing. - 21 Veterinary Issues and Anesthesia Options. - 22 Histological and Immunohistochemical Methods for Vascular Animal Model Studies.