Non-Natural Nucleic Acids

Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs. - Synthesis of Site-Specific Crown Ether Adducts to DNA Abasic Sites, 8-Oxo-7, 8-Dihydro-2 -Deoxyguanosine and 2 -Deoxycytidine. - Synthesis of a Fluorescent Cytidine TNA Triphosphate Analogue. - Synthesis of Base-Modified dNTPs through Cross-Coupling Reactions and Their Polymerase Incorporation to DNA. - 2 -
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-Ethyleneoxy-Bridged 2 -Deoxyribonucleic Acids (EoDNAs) with Thymine Nucleobases: Synthesis, Duplex-Forming Ability, and Enzymatic Stability. - Synthesis Protocols for Simple Uncharged Glycol Carbamate Nucleic Acids. - Synthesis of Nucleobase-Functionalized Morpholino Monomers. - Synthesis and Application of
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K T Peptide Nucleic Acids. - Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids. - Preparation and Purification of Oligodeoxynucleotide Duplexes Containing a Site-Specific, Reduced, Chemically-Stable Covalent Interstrand Cross-Link between a Guanine Residue and an Abasic Site. - Copper-Catalyzed Alkyne-Azide Cycloaddition on the Solid Phase for the Preparation of Fully Click-Modified Nucleic Acids. - Labeling Peptide Nucleic Acids with Indium-111. - Site-Specific Labeling of DNA via PCR with an Expanded Genetic Alphabet. - Flexible Nucleic Acids (FNAs) As Informational Molecules: Enzymatic Polymerization of fNTPs on DNA Templates and Nonenzymatic Oligomerization of RNA on FNA Templates. - Artificial Nucleosides as Diagnostic Probes to Measure Translesion DNA Synthesis. - FRET Assay for Ligands Targeting the Bacterial A-Site RNA. - The Use of Serinol Nucleic Acids as Ultrasensitive Molecular Beacons. - Oligonucleotide Primers with G
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-Clamp Modifications for RT-qPCR Detection of the Low-Copy dsRNA. - Determining Steady-State Kinetics of DNA Polymerase Nucleotide Incorporation.